Biotechnology can benefit from dynamic control to improve production efficiency. In this context, optogenetics enables modulation of gene expression using light as an external input, allowing fine-tuning of protein levels to unlock dynamic metabolic control and regulation of cell growth. Optogenetic systems can be actuated by light intensity. However, relying solely on intensity-driven control (i.e., signal amplitude) may fail to properly tune optogenetic bioprocesses when the dose-response relationship (i.e., light intensity versus gene-expression strength) is steep. In these cases, tunability is effectively constrained to either fully active or fully repressed gene expression, with little intermediate regulation. Pulse-width modulation, a concept widely used in electronics, can alleviate this issue by alternating between fully ON and OFF light intensity within forcing periods, thereby smoothing the average response and enhancing process controllability. Naturally, optimizing pulse-width-modulated optogenetics entails a switching-time optimal control problem with a binary input over many forcing periods. While this can be formulated as a mixed-integer program on a refined time grid, the number of decision variables can grow rapidly with increasing time-grid resolution and number of forcing periods, compromising tractability. Here, we propose an alternative solution based on reinforcement learning. We parametrize control actions via the duty cycle, a continuous variable that encodes the ON-to-OFF switching time within each forcing period, thereby respecting the intrinsic binary nature of the light intensity.

Microscale robots have a variety of potential applications in medicine, environmental monitoring, and tissue engineering, due to their small size and capabilities of sensing and manipulation at the small scale [1]. Recent research has demonstrated their potential in applications ranging from ocular drug delivery and in vitro fertilization to root canal prevention and tumor treatment [2, 3]. The most common actuation methods for microscale robots are acoustic and electromagnetic actuation [4]. Acoustic microrobots, for instance, can be manipulated using sound waves to achieve precise movements, while electromagnetic microrobots rely on magnetic fields for their actuation and control. Traditional open-loop control systems for acoustic and magnetic microrobots often fail to provide the necessary accuracy and reliability required for the above applications [5].

Mining 4.0 leverages advancements in automation, digitalization, and interconnected technologies from Industry 4.0 to address the unique challenges of the mining sector, enhancing efficiency, safety, and sustainability. Conveyor belts are crucial in mining operations by enabling the continuous and efficient movement of bulk materials over long distances, which directly impacts productivity. While detecting anomalies in specific conveyor belt components, such as idlers, pulleys, and belt surfaces, has been widely studied, identifying the root causes of these failures remains critical due to factors like changing production conditions and operator errors. Continuous monitoring of mining conveyor belt work cycles for anomaly detection is still at an early stage and requires robust solutions. This study proposes two distinctive pattern recognition approaches for real-time anomaly detection in the operational cycles of mining conveyor belts, combining feature extraction, threshold-based cycle detection, and tiny machine-learning classification. Both approaches outperformed a state-of-the-art technique on two datasets for duty cycle classification in terms of F1-scores. The first approach, with 97.3% and 80.2% for normal and abnormal cycles, respectively, reaches the highest performance in the first dataset while the second approach excels on the second dataset, scoring 91.3% and 67.9%. Implemented on two low-power microcontrollers, the methods demonstrated efficient, real-time operation with energy consumption of 13.3 and 20.6 ${\mu}$J during inference. These results offer valuable insights for detecting mechanical failure sources, supporting targeted preventive maintenance, and optimizing production cycles.

We investigate a method to modulate contact forces between the soft fingers of a two-finger gripper and an object, without relying on tactile sensors. This work is a follow-up to our previous results on contact detection. Here, our hypothesis is that once the contact between a finger and an object is detected, a controller that keeps a desired difference between the finger bending measurement and its bending at the moment of contact is sufficient to maintain and modulate the contact force. This approach can be simultaneously applied to both fingers while getting in contact with a single object. We successfully tested the hypothesis, and characterized the contact and peak pull-out force magnitude vs. the desired difference expressed by a multiplicative factor. All of the results are performed on a real physical device.

Real-time deepfake, a type of generative AI, is capable of "creating" non-existing contents (e.g., swapping one's face with another) in a video. It has been, very unfortunately, misused to produce deepfake videos (during web conferences, video calls, and identity authentication) for malicious purposes, including financial scams and political misinformation. Deepfake detection, as the countermeasure against deepfake, has attracted considerable attention from the academic community, yet existing works typically rely on learning passive features that may perform poorly beyond seen datasets. In this paper, we propose SFake, a new real-time deepfake detection method that innovatively exploits deepfake models' inability to adapt to physical interference. Specifically, SFake actively sends probes to trigger mechanical vibrations on the smartphone, resulting in the controllable feature on the footage. Consequently, SFake determines whether the face is swapped by deepfake based on the consistency of the facial area with the probe pattern. We implement SFake, evaluate its effectiveness on a self-built dataset, and compare it with six other detection methods. The results show that SFake outperforms other detection methods with higher detection accuracy, faster process speed, and lower memory consumption.

In the realm of electronic and electrical engineering, automation of analog circuit is increasingly vital given the complexity and customized requirements of modern applications. However, existing methods only develop search-based algorithms that require many simulation iterations to design a custom circuit topology, which is usually a time-consuming process. To this end, we introduce LaMAGIC, a pioneering language model-based topology generation model that leverages supervised finetuning for automated analog circuit design. LaMAGIC can efficiently generate an optimized circuit design from the custom specification in a single pass. Our approach involves a meticulous development and analysis of various input and output formulations for circuit. These formulations can ensure canonical representations of circuits and align with the autoregressive nature of LMs to effectively addressing the challenges of representing analog circuits as graphs. The experimental results show that LaMAGIC achieves a success rate of up to 96\% under a strict tolerance of 0.01. We also examine the scalability and adaptability of LaMAGIC, specifically testing its performance on more complex circuits. Our findings reveal the enhanced effectiveness of our adjacency matrix-based circuit formulation with floating-point input, suggesting its suitability for handling intricate circuit designs. This research not only demonstrates the potential of language models in graph generation, but also builds a foundational framework for future explorations in automated analog circuit design.

We present experimental results on the single file motion of a group of robots interacting with each other through position sensors. We successfully replicate the fundamental diagram typical of these systems, with a transition from free flow to congested traffic as the density of the system increases. In the latter scenario we also observe the characteristic stop-and-go waves. The unique advantages of this novel system, such as experimental stability and repeatability, allow for extended experimental runs, facilitating a comprehensive statistical analysis of the global dynamics. Above a certain density, we observe a divergence of the average jam duration and the average number of robots involved in it. This discovery enables us to precisely identify another transition: from congested intermittent flow (for intermediate densities) to a totally congested scenario for high densities. Beyond this finding, the present work demonstrates the suitability of robot swarms to model complex behaviors in many particle systems.

Despite the outstanding performance of deep neural networks, they are vulnerable to adversarial attacks. While there are many invisible attacks in the digital domain, most physical world adversarial attacks are visible. Here we present an invisible optical adversarial attack that uses a light source to dazzle a CMOS camera with a rolling shutter. We present the photopic conditions required to keep the attacking light source completely invisible while sufficiently jamming the captured image so that a deep neural network applied to it is deceived.

During virtual interactions, rendering haptic feedback on a remote location (like the wrist) instead of the fingertips freeing users' hands from mechanical devices. This allows for real interactions while still providing information regarding the mechanical properties of virtual objects. In this paper, we present CoWrHap -- a novel wrist-worn haptic device with custom-made voice coil actuation to render force feedback. Then, we investigate the impact of asking participants to use their dominant or non-dominant hand for virtual interactions and the best mapping between the active hand and the wrist receiving the haptic feedback, which can be defined as hand-wrist congruence through a user experiment based on a stiffness discrimination task. Our results show that participants performed the tasks (i) better with non-congruent mapping but reported better experiences with congruent mapping, and (ii) with no statistical difference in terms of hand dominance but reported better user experience and enjoyment using their dominant hands. This study indicates that participants can perceive mechanical properties via haptic feedback provided through CoWrHap.

The convective heat transfer in a turbulent boundary layer (TBL) on a flat plate is enhanced using an artificial intelligence approach based on linear genetic algorithms control (LGAC). The actuator is a set of six slot jets in crossflow aligned with the freestream. An open-loop optimal periodic forcing is defined by the carrier frequency, the duty cycle and the phase difference between actuators as control parameters. The control laws are optimised with respect to the unperturbed TBL and to the actuation with a steady jet. The cost function includes the wall convective heat transfer rate and the cost of the actuation. The performance of the controller is assessed by infrared thermography and characterised also with particle image velocimetry measurements. The optimal controller yields a slightly asymmetric flow field. The LGAC algorithm converges to the same frequency and duty cycle for all the actuators. It is noted that such frequency is strikingly equal to the inverse of the characteristic travel time of large-scale turbulent structures advected within the near-wall region. The phase difference between multiple jet actuation has shown to be very relevant and the main driver of flow asymmetry. The results pinpoint the potential of machine learning control in unravelling unexplored controllers within the actuation space. Our study furthermore demonstrates the viability of employing sophisticated measurement techniques together with advanced algorithms in an experimental investigation.